Mystery in Space is the name of two science fiction American comic book series published by DC Comics and a stand alone Vertigo anthology released in 2012. The first series ran for 110 issues from 1951 to 1966, with a further 7 issues continuing the numbering during a 1980s revival of the title. An 8-issue limited series began in 2006.
Together with Strange Adventures, Mystery In Space was one of DC Comics' major science fiction anthology series. It won a number of awards, including the 1962 Alley Award for "Best Book-Length Story" and the 1963 Alley Award for "Comic Displaying Best Interior Color Work". The title featured short science fiction stories and a number of continuing series, most written by many of the best-known comics and science fiction writers of the day, including John Broome, Gardner Fox, Jack Schiff, Otto Binder, and Edmond Hamilton. The artwork featured a considerable number of the 1950s and 1960s finest comics artists such as Carmine Infantino, Murphy Anderson, Gil Kane, Alex Toth, Bernard Sachs, Frank Frazetta and Virgil Finlay.