Launched as the fifth Marvel Sci-Fi anthology alongside Journey Into Mystery (Marvel, 1952 series), Tales of Suspense (Marvel, 1959 series), Tales to Astonish (Marvel, 1959 series) and Strange Tales (Marvel, 1951 series). Each book included a feature-length Kirby-drawn monster story, an ongoing Doctor Droom feature (which skipped one issue), and a short story drawn by Steve Ditko. This series introduced Doctor Druid (as Doctor Droom).
Marvel's first series of this title ran six issues, premiering with June 1961 cover-date. It featured primarily science fiction and drive-in movie-style monster stories, virtually all drawn by either Jack Kirby or Steve Ditko. Its first issue introduced the supernatural monster-hunter Doctor Droom, Marvel's first Silver Age of Comic Books superhero. Droom had powers of telepathy and hypnotic suggestion taught him by a Tibetan lama who had requested that someone travel from the U.S. to give him medical attention.
Doctor Droom vanished into obscurity for years when the comic was retitled and reformatted as Amazing Adult Fantasy from issues #7-14 (Dec. 1961 - July 1962). He resurfaced in the 1970s as Doctor Druid, having been renamed to avoid confusion with Doctor Doom. The series was retitled once more for its final issue, published as Amazing Fantasy #15 (Aug. 1962), the comic book that introduced Spider-Man.